Antioxidant cytoprotection by peroxisomal peroxiredoxin-5
نویسندگان
چکیده
منابع مشابه
Peroxiredoxin 1 – an antioxidant enzyme in cancer
Peroxiredoxins (PRDXs), a ubiquitous family of redox-regulating proteins, are reported of potential to eliminate various reactive oxygen species (ROS). As a major member of the antioxidant enzymes, PRDX1 can become easily over-oxidized on its catalytically active cysteine induced by a variety of stimuli in vitro and in vivo. In nucleus, oligomeric PRDX1 directly associates with p53 or transcrip...
متن کاملGastrointestinal cytoprotection by prostaglandins.
Prostaglandins (PGs) are widely distributed throughout the gastrointestinal tract and affect a variety of gastrointestinal functions. The observation that PGs of the E and A series are potent inhibitors of gastric acid secretion and that PGs, especially the E compounds, are released into the gastric lumen during vagal or gastrin stimulation suggests a possible physiological role for these agent...
متن کاملGastrointestinal Cytoprotection by PPARγ Ligands
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that is known to play a central role in lipid metabolism and insulin sensitivity as well as inflammation and cell proliferation. According to the results obtained from studies on several animal models of gastrointestinal inflammation, PPARγ has been implicated in the regulation of the immune response, particularly inflam...
متن کاملCyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence
Hystidyl-proline [cyclo(His-Pro)] is an endogenous cyclic dipeptide produced by the cleavage of thyrotropin releasing hormone. Previous studies have shown that cyclo(His-Pro) protects against oxidative stress, although the underlying mechanism has remained elusive. Here, we addressed this issue and found that cyclo(His-Pro) triggered nuclear accumulation of NF-E2-related factor-2 (Nrf2), a tran...
متن کاملThe yeast Tsa1 peroxiredoxin is a ribosome-associated antioxidant.
The yeast Tsa1 peroxiredoxin, like other 2-Cys peroxiredoxins, has dual activities as a peroxidase and as a molecular chaperone. Its peroxidase function predominates in lower-molecular-mass forms, whereas a super-chaperone form predominates in high-molecular-mass complexes. Loss of TSA1 results in aggregation of ribosomal proteins, indicating that Tsa1 functions to maintain the integrity of the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2015
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2015.02.032